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Ophthalmic Drug Ingredients

Leading Exporter of cromolyn sodium, diclofenac sodium, flurbiprofen, ketorolac tromethamine, ketotifen hydrogen fumarate and methazolamide from Mumbai.
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Cromolyn Sodium

Cromolyn Sodium
 
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Approx. Rs 15,500 / KilogramGet Latest Price

Product Details:
UsageLaboratory
Grade StandardAnalytical Grade
Packaging Size1 Kg Bottles
Physical StatePowder
Packaging TypeBottles
Melting Point241-2420C (dec)
ColorWhite
Molecular Weight248.3
AppearanceWhite Crystalline Powder
Boiling Point752.3 Degree C at 760 mmHg
Flash Point263.9 Degree C

Cromolyn sodium is a stabilizer of mast cell membrane. Cromolyn sodium has been used to treat for asthma for many years. It is a derivative of khellin and is proved to be a unique antiallergic agent. The prior administration of cromolyn sodium inhibits allergen-induced histamine release in the animal experiments. Because the oral absorption of cromolyn sodium is minimal and only the powder form of it is available, cromolyn sodium is usually used through being inhaled from a special apparatus. Cromolyn sodium can suppress both immediate and late-onset asthmatic responses and suppress the release of NCF-A. It also inhibits the impairment of mucociliary transport induced by specific bronchial challenge. Moreover, cromolyn sodium also ameliorates exercise-induced asthma.
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Diclofenac Sodium

Diclofenac Sodium
 
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Approx. Rs 1,300 / KilogramGet Latest Price

Product Details:
Dosage FormPowder
Usage/ApplicationOphthalmic Drug Ingredients
Manufacturing ProcessChemical Synthesis
Packaging Size1 Kg
Packaging TypeBottles
UsageLaboratory
Melting Point275-277
AppearanceWhite crystalline powder
Heavy MetalMax 10ppm
Loss on dryingMax 0.5%
Related SubstancesSingle impurity max 0.2%,Total impurity max 0.5%

Diclofenac (sold under a number of trade names) is a nonsteroidal anti-inflammatory drug (NSAID) taken or applied to reduce inflammation and as an analgesic reducing pain in certain conditions. It is supplied as or contained in medications under a variety of trade names.

Specifications:

Solubility

Sparingly soluble in water, freely soluble in methanol, ethanol(96%); slightly soluble in acetone; practically insoluble in ether

Identify:

(A) IR-Spectrum

(D) Reaction of sodium salt

4Acidity or alkalinity

6.5-7.5

Appearance of solution

Absorption of sodium salt≤0.05

Assay(by HPLC)

≥98.5%

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Flurbiprofen

Flurbiprofen
 
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Approx. Rs 6,600 / KilogramGet Latest Price

Product Details:
Packaging Size1 Kg
Usage/ApplicationOphthalmic Drug Ingredients
Physical StatePowder
Manufacturing ProcessChemical Synthesis
UsageLaboratory
Packaging Type1 Kg
ColorWhite
Pack SizeBottles
Melting Point110 - 112 Degree C
Purity99%
Molecular Weight244.26

Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs). It is primarily indicated as a pre-operative anti-miotic (in an ophthalmic solution) as well as orally for arthritis or dental pain. Side effects are analogous to those of ibuprofen.

 

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Ketorolac Tromethamine

Ketorolac Tromethamine
 
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Approx. Rs 18,000 / KilogramGet Latest Price

Product Details:
Packaging Size1 Kg
Usage/ApplicationOphthalmic Drug Ingredients
Physical StatePowder
Manufacturing ProcessChemical Synthesis
UsageLaboratory
Packaging TypeBottles
ColorWhite
Purity99% Ketorolac tromethamine
AppearanceKetorolac tromethamine powder
CAS No74103-07-4
Shelf Life2 years for Ketorolac tromethamine
SynonymsKetorolac tromethamine

Ketorolac (tromethamine salt) inhibits both isoforms of Cox in recombinant rat and human enzyme systems. Ketorolac inhibits rat Cox-1 (IC50 of 0.27 μM), rat Cox-2 (IC50 of 2.06 μM), human Cox-1 (IC50 of 1.23 μM) and human Cox-2 (IC50 of 3.50 μM). The (S) enantiomer of Ketorolac with rat Cox-1 (IC50 of 0.10 μM) is approximately twice as potent as the racemate, whereas the (R)-enantiomer (IC50 of > 100 μM) is virtually without activity. Ketorolac shows inhibition of eicosanoid formation in HEL cells (Cox-1, IC50 of 0.025 μM) and LPS-stimulated Mono Mac 6 cells (Cox-2, IC50 of 0.039 μM), but does not significantly inhibit NO accumulation in supernatants of LPS-stimulated RAW 264.7 cells up to 300 μM. Ketorolac significantly inhibits thymidine incorporation of human osteoblasts (hOBs) upon 24 hours treatment in a dose-dependent manner, and inhibits proliferation and arrests cell cycle at G0/G1 phase in hOBs.

Pharmaceutical Raw Materials,Active Pharmaceutical Ingredients,Bulk Drugs,Fine Chemicals.

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Ketotifen Hydrogen Fumarate

Ketotifen Hydrogen Fumarate
 
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Approx. Rs 64,000 / KilogramGet Latest Price

Product Details:
Usage/ApplicationOphthalmic Drug Ingredients
Manufacturing ProcessChemical Synthesis
Packaging Type1 Kg
Packaging Size1 Kg
UsageLaboratory
Molecular FormulaC19H19NOS.C4H4O4;C23H23NO5S
Product TypeAPI
Molecular Weight425.50
BrandSalus
CAS Registry Number34580-14-8

Ketotifen is a first-generation noncompetitive H1-antihistamine and mast cell stabilizer. It is most commonly sold as a salt with fumaric acid, ketotifen fumarate, and is available in two forms. In its ophthalmic form, it is used to treat allergic conjunctivitis.In its oral form, it is used to prevent asthma attacks or Anaphylaxis, as well as various mast cell, allergic-type disorders.

Synonyms:

  • 4-(1-Methyl-4-piperidylidene)-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one hydrogen fumarate

 

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Methazolamide

Methazolamide
 
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Approx. Rs 1.3 Lakh / KilogramGet Latest Price

Product Details:
Packaging Size1 Kg
Usage/ApplicationOphthalmic Drug Ingredients
Physical StatePowder
Manufacturing ProcessChemical Synthesis
UsageLaboratory
Packaging TypeBottles
ColorWhite
Purity99% Methazolamide
AppearanceMethazolamide powder
CAS No554-57-4
Shelf Life2 years for Methazolamide

Methazolamide is a potent carbonic anhydrase inhibitor. It is indicated in the treatment of increased intraocular pressure in chronic open-angle glaucoma and secondary glaucoma. Also it is used preoperatively in acute angle-closure glaucoma where lowering the IOP is desired before surgery.
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Mitomycin C

Mitomycin C
 
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Approx. Rs 3 Lakh / KilogramGet Latest Price

Product Details:
Packaging Size1 Kg
Usage/ApplicationOphthalmic Drug Ingredients
Physical StatePowder
Manufacturing ProcessChemical Synthesis
UsageLaboratory
Packaging TypeDrum
ColorWhite
Type Of APIInnovative
Melting Point360 Degree C
FormulaC15H18N4O5
Molar Mass334.33 g/mol

Description:

  • Mitomycin C is a broad-spectrum anti-tumor antibiotics extracted from Streptoverticillium caespitosus, with genetic toxicity and anti-tumor activity, which is generally recognized as an inhibitor of DNA damage, and has anticancer effects to a variety of cancers. When activated, it can play the role of DNA alkylating agent, depolymerizing DNA, inhibiting DNA, cellular RNA and protein synthesis selectively, thus to inhibit tumor cell division.
  • This product is a cell cycle nonspecific agents with broad anti-tumor spectrum and rapid effects, while low treatment index and high toxicity. It is clinically applied to digestive tract cancer, such as gastric cancer, colon cancer, liver cancer and pancreatic cancer, and has a better efficacy. It is also effective for lung cancer, breast cancer, cervical cancer and chorionic epithelioma. It Can also be applied to malignant lymphoma and malignant pleural effusions.

 


Specifications:

TEST ITEMS

SPECIFICATIONS

RESULTS

Characteristics

Violet-blue crystal

Conforms

Identification

Complies with the test for identification of mitomycin

Conforms

Crystallinity

Conforms

Conforms

PH

6.0-7.5

6.6

Water

≤2.5%

0.1 %

Assay

≥970μg/mg

991μg/mg

CONCLUSION

CONFORM TO USP32


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Naphazoline Hydrochloride

Naphazoline Hydrochloride
 
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Approx. Rs 43,000 / KilogramGet Latest Price

Product Details:
Molecular FormulaC14H14N2.HCl
Melting Point254-260 Degree C
Purity99%min
Shelf Life2 Years Proper Storage
AppearanceWhite crystalline powder
EINECS No208-989-2
CAS No550-99-2

Naphazoline Hydrochloride is the common name for 2-(1-naphthylmethyl)-2-imidazoline hydrochloride. It is a sympathomimetic agent with marked alpha adrenergic activity. It is a vasoconstrictor with a rapid action in reducing swelling when applied to mucous membrane. It acts on alpha-receptors in the arterioles of the conjunctiva to produce constriction, resulting in decreased congestion.

Specifications:

Other Name

2-(1-Naphthylmethyl)imidazoline hydrochloride

Storage

It should be stored in a well-closed container at low temperature, keep away from moisture, heat and light.

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Timolol Maleate

Timolol Maleate
 
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Approx. Rs 45,000 / KgGet Latest Price

Product Details:
Grade StandardAnalytical Grade
Packaging Size1 Kg
Physical StatePowder
Packaging TypeBottles
ColorWhite
Purity99% Timolol maleate
Type Of APIOphthalmic Drug Ingredients
Chemical NameTIMOLOL MALEATE
AppearanceTimolol maleate powder
CAS No26839-77-0
Shelf life2 years

Timolol maleate is clinically used for the treatment of hypertension, angina, tachycardia and glaucoma. Good efficacy for mild to moderate hypertension, no obvious adverse reactions, can be combined with diuretics. The long-term use of drugs in patients with myocardial infarction can reduce the incidence of re-infarction and mortality. It has a good effect on glaucoma, especially primary and open-angle glaucoma, and is superior to traditional eye drop pressure drugs. It is characterized by rapid onset, less adverse reactions, better tolerance, and no effect on pupil size, response to light, and vision. For some secondary glaucoma, ocular hypertension and other drugs and surgery ineffective glaucoma also have a certain effect.

Specifications:

Category

Pharmaceutical Raw Materials,Active Pharmaceutical Ingredients,Bulk Drugs,Fine Chemicals.

Usage

Timolol maleate is a non-selective beta-adrenergic receptor antagonist indicated for treating glaucoma, heart attacks, hypertension, and migraine headache.

Storage

Timolol maleate should be stored in a well-closed container at low temperature, keep away from moisture, heat and light.

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Acetazolamide

Acetazolamide
 
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Approx. Rs 3,700 / KilogramGet Latest Price

Product Details:
Usage/ApplicationOphthalmic Drug Ingredients
Packaging Size1 kg
Medicine TypeOphthalmic Drug Ingredients
MaterialPure
Product TypeOphthalmic Drug Ingredients
Packaging TypeBottles
Molecular FormulaC4H6N4O3S2
Purity99%
Molecular Weight222.24
AppearanceWhite crystalline powder
CAS No59-66-5

It is used in the treatment of glaucoma, drug-induced edema, heart failure-induced edema, epilepsy and in reducing intraocular pressure after surgery. It has also been used in the treatment of mountain sickness, Ménière's disease, increased intracranial pressure and neuromuscular disorders. In epilepsy, the main use of acetazolamide is in menstrual-related epilepsy and as an add on to other treatments in refractory epilepsy.
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